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Detoxes are all the rage these days. Usually they involve some sort of extreme behavior — you have to limit your calories, or your carbohydrate intake, or your red meat intake… or you have to sweat out the toxins with intense exercise, or flush them out with diuretics and enemas, or burn them out with cayenne pepper and lemon juice.


The thing about 99% of detoxes is that they plain old get detox wrong. In what way do any of the cleansing methods I mentioned above actually support a healthy body?

The short answer is that they don’t.

There is, however, a real detox method already up and running in your body. Your body is already doing a lot of hard work. So why play around with other stuff? The only smart way to detox and improve your health is to support the organs in your body that actually detox you on a regular basis.

What detox does for you

All the fuss about detox is, to be fair, for a pretty good reason, I think. The modern world is full of chemicals that the human body was never exposed to in it’s natural environment. The toxin load we all bear is greater than the body was built for. This doesn’t mean that your body can’t cope… but it does mean that it’s probably best to support it as best as possible.

Detox clears heavy metals and other toxic substances (including natural byproducts of metabolism) out of your body. Toxins hang around in fat cells as “storage,” much of the time, but in the places they are stored this can be quite dangerous. They are quite easily be stored in the brain and in the body’s glands, for example. These are probably the last two places any of us want toxins to be hanging around. Here they can cause fatigue, dizziness, nausea, mood disorders, mental disorders, adrenal dysregulation, and many other problems.

Supporting detox can help eliminate these problems.

The body’s detox process also helps keep hormone levels in balance. If you properly support detox, you can help eliminate estrogen dominance, symptoms of PMS, mood swings, and symptoms of testosterone excess like facial hair and acne. You can also increase your libido and your fertility.

Finally – it really is no lie. A healthy detox process is a huge help to healthy skin, mostly because it permits your body the antioxidants it needs to fight off inflammation and free oxygen radicals in all of your tissues, including your skin.

How detox works

Toxins like mercury are usually fat-soluble. This means that they bond to fat molecules and not to water (molecules will usually bond to one or the other). It should come as no surprise then that toxins are stored in fat cells. This also explains why people who undergo weight loss, who fast for extensive periods, or who exercise excessively sometimes experience symptoms of toxicity. The toxins are released into the bloodstream as the fat is burned off.

The liver is the superhero of the detox story. It is pretty much the sole organ responsible for getting rid of these toxins. How? It converts them from fat-soluble to water-soluble. Then, when water-soluble, your body can excrete them out in urine. This is pretty cool stuff. It does this in two primary ways:

Phase 1: Modification

With the help of enzymes in the P450 group, the  body conducts a number of chemical reactions that convert a toxin like mercury into something a bit less toxic.

However: this process produces free oxygen radicals, so anti-oxidants are absolutely crucial for supporting the body while it detoxes. If left unchecked, the free oxygen radicals can cause just as much damage as the toxins themselves.

This “phase 1” is conducted by the body on a regular basis. It’s perfectly healthy for the liver to process a safe number of toxins on a daily basis. For example, “old” estrogen and testosterone are processed by the liver every day.

Yet toxins become problematic for the body when this system is overwhelmbed. When overwhelmed, the system goes into over-drive but is still backlogged, leaving the body both flooded with toxins as well as free radicals.

There are lots of things that can overload this system. They include alcohol, cigarettes, exhaust fumes, pesticides, barbituates, narcotics, dioxin, trans fats, and even caffeine in high doses. These substances are obviously best avoided as much as possible.

What to do about it

In order to support your body throughout this phase, ample cruciferous vegetables (at least three servings a day), red meat for iron and B vitamins (especially riboflavin and niacin), and magnesium perhaps from a suplement like this one would all be an excellent help.

Exercise helps keeps bloodflow strong and healthy, which speeds the processing of toxins in the liver and keeps everything moving efficiently. Be sure to walk places as often as possible and to practice some high intensity exercises and weight lifting at least a few times every week.

Some substances actively inhibit the activity of cytochrome P450, most notably of which being grapefruit. Of course it’s fine to consume grapefruit. Of course. Yet if you have a weak liver or are trying to detox, you would probably do best to limit your consumption of it.

Phase 2: Add a molecule

The other way the liver detoxes the body is by adding a harmless molecule like an amino acid to a toxin, which renders it less harmful, and also water soluble, so it can be excreted.

This is the detox aspect of the body that utilizes glutathione – one of the molecules most closely studied for it’s powerful anti-oxidant and healing effects in the body. It is quite literally the most powerful protective agent in the entire body. Unfortunately you cannot simply take a glutathione supplement and watch your worries melt away. Fortunately however you can support this pathway and all the molecules you need for healthy glutathione activity.

What to do about it

One of the best things you can do for this part of the process is to focus on sulfur-containing foods, since sulfur-containing amino acids are crucial for this process. Leafy greens, garlic, onions, shallots, leaks, and also egg yolks are all extremely high in sulfur.

Choline, found in egg yolks and beef liver, is also a huge help to this process.

Ample animal protein – at least 100 grams or 16 oz a day – so you can obtain all the amino acids you need is also critical.

N-acetyl cysteine is great for both aspects of detox and is an excellent supplement to consider taking for antioxidant and detox support (as well as clear skin!).

Consider supplementing with curcumin, which has been shown to help support the liver and its detox capabilities.

Fasting may deplete glutathione and other powerhouses (because they work on overtime), so I personally recommend steering away from extreme fasting. Intermittent fasts for many people work well (though not always for women, as I discuss here).

Detox in context

Now… I’ve talked all about the liver and environmental, heavy-metal type detoxification here. This is real and important stuff, and supporting your body through it could be one of the most important things you do for your health.

Yet of course this all occurs in context. In order to have a healthy functioning liver and detox system, it helps to have a healthy digestive system and a healthy immune system (and, to be fair, just about all of the systems).

You can support your gut by eliminating gut irritating foods like grains and dairy from your diet, as well as by eating bacteria-rich probiotic foods like kimchi, sauerkraut, kefir, coconut yogurt, or kombucha on a daily basis (or supplementing with a probiotic.

You can support your immune system in a number of ways. The most important might be to eliminate seed and vegetable oils from your diet, and to focus on eating fatty, wild-caught fish several times a week or taking an excellent cod liver oil supplement. You should also try to get at least 20 minutes of noontime sun every day for healthy vitamin D production, or you can take a supplement. Zinc is also an excellent way to support the immune system.

All in all, the body is a complex system with many different ways to support healthy detox. The more you can nourish your body on a regular basis, the better. Detox isn’t about a five day cleanse…. it’s about a nourishing diet to last a life time. Focus on a diet rich in produce and whole, grass-fed animal products, and you’ll do far more for your body than if you sucked on a lemon with some cayenne pepper every day for the rest of your life.

To recap, if you decide to supplement, here are my faves:

N-Acetyl Cysteine (my favorite)



Fermented Cod Liver Oil



How to Do a REAL Detox in 3 Steps - Paleo for Women

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